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Concanavalin A (Con A) has been found to enhance blastogenesis or Ag-specific helper and suppressor activity of T lymphocytes. The study examined the effect of Con A on lymphocyte blastogenesis in vitro and on antigen-specific cytolytic activity of spleen cells, using a murine leukemia virus-induced murine T leukemia lymphoma cell line, L-5178Y, as the target. Pre-incubation of lymphocytes with Con A enhanced their blastogenic response to various polyclonal activators as measured by DNA synthesis. However, Con A was relatively ineffective as an antigen-specific stimulator of T-dependent cytolytic activity. The results suggest that the effect of Con A on cytotoxicity may be mediated by various lymphocyte subpopulations.