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Please enter your username and password.. My Brother The Devil was never aired on television in Brazil, but a dubbed version was aired on Lifetime TV from July 1, 2009 to January 6, 2010.Although there is a strong epidemiological association between cannabis use and psychosis, there is a lack of longitudinal prospective data on the effects of exposure to cannabis on the course of first episode psychosis. Retrospective data have shown that many patients who report cannabis abuse/dependence have had prolonged symptomatology during the prodromal phase of illness in the form of non-negative symptoms and mood disturbance. Pre-clinical models have also indicated that cannabis may have negative effects on the temporal course of first episode schizophrenia, with a possible delayed emergence of psychotic symptoms. Furthermore, neuroimaging studies of effects of cannabis use have suggested that people who use cannabis are at risk for enduring abnormal brain functioning, including structural alterations and increased signal in key brain structures involved in the pathophysiology of psychotic symptoms. The goal of the study is to examine whether patients who use cannabis are at risk for having a prolonged duration of untreated psychosis (DUP) compared with patients who do not use cannabis, and to determine whether the chronic effects of cannabis use on brain structures in first episode psychosis are correlated with and predictive of symptom development. In this prospective naturalistic study, we will recruit 36 patients with their first ever episode of a schizophrenia spectrum disorder from the community. They will be assessed weekly for the first two months following their index contact with the mental health service to assess for the presence of positive and negative symptoms and premorbid adjustment. Cannabis users will be asked about the quantity and frequency of cannabis use. C-Sat and other magnetic resonance imaging (MRI) measures will be collected at entry into the study and at 6 months follow-up. The length of time from the first contact to the first episode will be measured for all participants and for patients with cannabis use compared to patients without cannabis use. There
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