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Published: 25 juillet 2022 (3 semaines ago)
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The most common chemical in our drinking water is sodium, with too much of this mineral causing high blood pressure, heart attack, strokes and other negative effects. Drinking the recommended amount of water of course reduces the sodium content of the body.

Lead and mercury are also commonly found in water, both of which are highly toxic to the human body. Flint, Michigan, is the most infamous example of this, where poor water quality has resulted in a high rate of lead poisoning.

Now a new study from the University of Georgia shows what happens when people drink water contaminated with arsenic.

The study, « Hematologic and renal effects of chronic arsenic exposure in rats, » was published in the journal Environmental Health. The researchers examined the effects of chronic arsenic exposure in rats, which exposes them to approximately 500 to 600 micrograms of the chemical per day. Chronic exposure is the kind that happens over long periods of time, as opposed to acute exposure that happens over short periods.

Arsenic is a common heavy metal, meaning it’s toxic even at low levels. The body absorbs arsenic primarily through the skin, and is also poisonous when inhaled and comes in contact with the eyes.

The study shows how arsenic exposure causes damaged kidneys, that increases over time, eventually leading to renal dysfunction, poor kidney health and even death.

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Arsenic also decreased the quantity of the blood cells called erythrocytes (red blood cells), which is something that happens in humans with chronic high blood pressure. The researchers say that arsenic may be a contributing factor of hypertension in humans.

« This may be a first finding of how chronic arsenic exposure can promote hypertension in humans, but it remains to be seen if its effects on the kidney translate to a mechanism of blood pressure elevation in humans, » said lead author Susan Davis, professor and chair of the UGA Department of Biochemistry.

Davis

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2,3,7,8-tetramethyl-6-ethyl-1,4-benzoquinone as a « multitasking » free-radical generator.
Precipitation of 2,3,7,8-tetramethyl-6-ethyl-1,4-benzoquinone with sodium carbonate from its ethanol solution results in two equimolar amounts of the carbonate and the quinone. These products are stable in air and do not react with themselves. The quinone undergoes a one-electron oxidation at trace oxygen concentrations and acts as a free-radical generator for the detection of trace quantities of atmospheric oxygen. A striking feature of the quinone is its ability to reduce cyclohexadienyl iron(III) to iron(II), which is detected at high field in EPR spectroscopy.1. Field of the Invention
The present invention generally relates to methods for altering cell and tissue morphology and for enhancing the recovery of cellular function following exposure to stimuli that trigger cell death or induce cellular stress. The present invention specifically relates to the novel use of adenoviruses and adeno-associated viruses for delivering proteins or antisense nucleic acids that trigger cell death or induce cellular stress and use of such adenoviruses and adeno-associated viruses for increasing the potency of a therapeutic agent.
2. Related Art
Although viruses are among the most potent inducers of cell death, the use of viral vectors has been limited to the delivery of genes for the treatment of inherited diseases. Generally, the major difficulty in using viruses as delivery systems is that viral genomes are too large to be packaged into viral capsids. Consequently, it has been extremely difficult to obtain sufficient numbers of virions that are devoid of viral genome contamination.
Viruses are also generally poorly tolerated in vivo. In particular, recombinant viruses often display low and short-lived expression. Additionally, some viral proteins may be immunogenic. Thus, in vivo administration of replication-competent virus has been associated with undesirable side-effects. Moreover, certain viruses are known to cause diseases. For example, viruses, such as the human immunodeficiency virus, the Hepatitis B virus, and adenovirus are associated with the development of acquired immune deficiency syndrome (AIDS), cirrhosis and cancer, respectively.
It is known in the art that adenoviruses have been used as gene transfer vehicles in vivo and

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